Welcome to the Tan laboratory at the Children's Hospital of Philadelphia and the University of Pennsylvania Perelman School of Medicine. Gene regulation plays a major role in development and cancer. Our lab uses genomics and systems biology approaches to studying gene regulation. We take snapshots of the regulatory systems using multiple types of bulk and single-cell omics and imaging assays. We develop various computational algorithms to integrate data and generate predictive and testable models of gene regulatory pathways. These efforts will help us better understand how the different processes controlling gene expression are coordinated in the cell and deepen our knowledge of organismal development and disease processes.

  • CSI-ANN algorithm for identifying functional DNA sequences based on their chromatin modification signatures. Firpi et al. Bioinformatics. 2010.