Welcome to the Tan laboratory at the Children's Hospital of Philadelphia and the University of Pennsylvania Perelman School of Medicine. Research in our lab is directed towards understanding gene regulatory networks in normal and disease development. In particular, we would like to gain mechanistic understanding of how genetic and epigenetic factors interact to control gene expression. These efforts will help us better understand how the different processes controlling gene expression are coordinated in the cell and deepen our knowledge of organismal development and disease processes. Towards this overall goal, we are conducting interdisciplinary research that combines wet-lab experiments and computation.

  • IM-PET algorithm for predicting enhancer-promoter interactions. He et al. PNAS. 2014.